*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AA5250000
CHEMICAL NAME           : Abrin
CAS REGISTRY NUMBER     : 1393-62-0
LAST UPDATED            : 199512
DATA ITEMS CITED        : 12
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
                          Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Abrins
   * Agglutinin
   * Crab's Eyes
   * Indian licorice seed
   * Jumble bead
   * Prayer bead
   * Toxalbumin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 7 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,2,1989
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - peritonitis
   Behavioral - muscle weakness
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,468,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 9,97,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(1),107,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 13,127,1975
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - peritonitis
   Behavioral - muscle weakness
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,468,1955
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75060 ug/kg/90D-I
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
   Blood - changes in platelet count
REFERENCE :
   EJVSAU Egyptian Journal of Veterinary Science. (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.9-
   1972-  Volume(issue)/page/year: 24,138,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6672 ug/kg
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   EJVSAU Egyptian Journal of Veterinary Science. (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.9-
   1972-  Volume(issue)/page/year: 24,135,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 50 ug/kg
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 11,379,1973
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 10 ug/L
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   57,328,1985
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 10 ug/L
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   57,328,1985

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   BIPAA8 Bulletin de l'Institut Pasteur (Paris).  (SPPIF, B.P.22, F-41353
   Vineuil, France) V.1-    1903-  Volume(issue)/page/year: 74,85,1976

 
                            *** END OF RECORD ***