*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AB7012500
CHEMICAL NAME           : Acetamide,
                          2-(diethylamino)-N-(1,3-dimethyl-4-(o-fluorobenzoyl)-
                          5-pyrazolyl)-, monohydrochloride
CAS REGISTRY NUMBER     : 103416-59-7
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H23-F-N4-O2.Cl-H
MOLECULAR WEIGHT        : 382.91
WISWESSER LINE NOTATION : T5NNJ B1 CMV1N2&2 DVR BF& E1 &GH
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   2-(Diethylamino)-N-(1,3-dimethyl-4-(o-fluorobenzoyl)-5-pyrazolyl)acetami
     de hydrochloride
   *   2-(Diethylamino)-N-(4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl)ace
     tamide hydrochloride
   * PD 109394
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4550 mg/kg/13W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   AJPAA4 American Journal of Pathology.  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1925-
   Volume(issue)/page/year: 124,392,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 7,2019,1986
 
                            *** END OF RECORD ***