*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AC2976200
CHEMICAL NAME           : Acetamide, N,N'-hexamethylenebis-
CAS REGISTRY NUMBER     : 3073-59-4
BEILSTEIN REFERENCE NO. : 1775764
REFERENCE               : 4-04-00-01331 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H20-N2-O2
MOLECULAR WEIGHT        : 200.32
WISWESSER LINE NOTATION : 1VM6MV1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Acetamide, N,N'-1,6-hexanediylbis-
   * N,N'-Diacetylhexamethylenediamine
   * Hexamethylenebisacetamide
   * N,N'-Hexamethylenebisacetamide
   * Hexamethylenediacetamide
   * N,N'-1,6-Hexanediylbisacetamide
   * NSC-95580
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 4270 mg/kg/10D-C
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - thrombocytopenia
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,5788,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 3,263,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 3,263,1985
 
                            *** END OF RECORD ***