*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AC3325000
CHEMICAL NAME           : Acetamide,
                          2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimeth
                          ylphenethyl)-N-methyl-
CAS REGISTRY NUMBER     : 126-27-2
BEILSTEIN REFERENCE NO. : 2404063
REFERENCE               : 4-12-00-02822 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C28-H41-N3-O3
MOLECULAR WEIGHT        : 467.72
WISWESSER LINE NOTATION : R1X1&1&N1&V1N2Q1VN1&X1&1&1R
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetamide,  
   2,2'-(2-hydroxyethyl)imino)bis(N-(1,1-dimethylphenylethyl)-N-methyl-
   * Betalgil
   * N,N-Bis(N-methyl-N-phenyl-tert-butylacetamido)-beta-hydroxyethylamine
   * 2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol
   * Emoren
   * FH 099
   * H4 099
   *   2,2'-((2-Hydroxyethyl)imino)bis(N-(alpha,alpha-dimethylphenethyl)-N-meth
     ylacetamide)
   *   2,2'-((2-Hydroxyethyl)imino)bis(N-(1,1-dimethyl-2-phenylethyl)-N-methyla
     cetamide)
   * Mucaine
   * Mucoxin
   * Mutesa
   * Muthesa
   * Oxaine
   * Oxetacaine
   * Oxethacaina
   * Oxethacaine
   * Oxethazaine
   * Oxethazine
   * Stomacain
   * Tepilta
   * Topicain
   * WY 806
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,283,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,283,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82267
       No. of Facilities: 838 (estimated)
       No. of Industries: 2
       No. of Occupations: 5
       No. of Employees: 29119 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82267
       No. of Facilities: 32 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1056 (estimated)
       No. of Female Employees: 490 (estimated)

 
                            *** END OF RECORD ***