*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AC3350070
CHEMICAL NAME           : Acetamide, N-(7-hydroxy-9H-fluoren-2-yl)-
CAS REGISTRY NUMBER     : 363-49-5
BEILSTEIN REFERENCE NO. : 2809478
REFERENCE               : 4-13-00-02237 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H13-N-O2
MOLECULAR WEIGHT        : 239.29
WISWESSER LINE NOTATION : L B656 HHJ EQ KMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 7-Hydroxy-2-acetaminofluorene
   * 7-Hydroxy-N-2-fluorenylacetamide
   * N-(7-hydroxy-9H-fluoren-2-yl)acetamide
   * 7OH-2AAF
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   1,391,1947
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,893,1979
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,873,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine
   reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human
   fibroblast
   
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9

 
                            *** END OF RECORD ***