*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AC6350000
CHEMICAL NAME           : Acetamide, N-(4-methyl-2-sulfamoyl-delta(sup
                          2)-1,3,4-thiadiazolin-5-ylidene)-
CAS REGISTRY NUMBER     : 554-57-4
BEILSTEIN REFERENCE NO. : 0232387
REFERENCE               : 4-27-00-08221 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C5-H8-N4-O3-S2
MOLECULAR WEIGHT        : 236.29
WISWESSER LINE NOTATION : T5NNYSJ B CUNV1 ESZW
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetamide, N-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene)-
   * 2-Acetylimino-3-methyl-delta(sup 4)-1,3,4-thiadiazoline-5-sulfonamide
   * 5-Acetylimino-4-methyl-delta(sup 2)-1,3,4-thiadiazoline-2-sulfonamide
   * Methazolamide
   * Methenamide
   * Naptazane
   * Neptazane
   * Neptazaneat
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2420 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,351,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,819,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7129
       No. of Facilities: 10 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 197 (estimated)
       No. of Female Employees: 59 (estimated)

 
                            *** END OF RECORD ***