*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BR7875000
CHEMICAL NAME           : Ammonium,
                          ((2-methyl-1,3-dioxolan-4-yl)methyl)trimethyl-,
                          iodide
CAS REGISTRY NUMBER     : 4386-79-2
LAST UPDATED            : 199112
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C8-H18-N-O2.I
MOLECULAR WEIGHT        : 287.17
WISWESSER LINE NOTATION : T5O COTJ B1 D1K1&1&1 &Q &I
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ammonium, trimethyl((2-methyl-1,3-dioxolan-4-yl)methyl)-, iodide
   * 1,3-Dioxolane-4-methanaminium, N,N,N,2-tetramethyl-, iodide
   * Ethyl-gamma-trimethylammonium propanediol iodide
   * F 2268
   * Fourneau 2268
   * Iodure de l'ethylal de gamma-trimethylammonium-propanediol
   * ((2-Methyl-1,3-dioxolan-4-yl)methyl)trimethylammonium iodide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,287,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01810
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,410,1948
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 75 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   BSCIA3 Bulletin de la Societe de Chimie Biologique.  (Paris, France) V.1-52,
   1914-70.  For publisher information, see BICMBE. Volume(issue)/page/year:
   26,516,1944
 
                            *** END OF RECORD ***