*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BR8050000
CHEMICAL NAME           : Ammonium,
                          ((methylimino)diethylene)bis(ethyldimethyl-,
                          dibromide
CAS REGISTRY NUMBER     : 306-53-6
LAST UPDATED            : 199203
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C13-H33-N3.2Br
MOLECULAR WEIGHT        : 391.31
WISWESSER LINE NOTATION : 2K1&1&2N1&2K2&1&1 &E 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Azamethone
   * Azamethonium bromide
   * Azameton
   * C 9295
   * Ciba 9295
   * Ethanaminium, 2,2'-(methylimino)bis(N-ethyl-N,N-diemthyl-, dibromide
   * Ganlion
   * 3-Methyl-3-azapentane-1,5-bis(ethyldimethylammonium bromide)
   * ((Methylimino)diethylene)bis(ethyldimethylammonium bromide)
   * Pendiomid
   * Pendiomide
   * Pendiomide bromide
   * Pendiomide dibromide
   * Pentamethazene dibromide
   * Pentamethazine
   * N,N,N',N',3-Pentamethyl-N,N'-diethyl-3-azapentylene-1,5-diammonium  
   dibromide
   * Pentamin
   * Pentamine
   * Pentamon
   * Pentomid
   * Prapar
   * Praparat 9295
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   21,110,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITDAQ Archiwum Immunologii i Terapii Doswiadczalnej.  (Warsaw, Poland)
   V.1-9, 1953-61.  For publisher information, see AITEAT.
   Volume(issue)/page/year: 4,391,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 21,8,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 81,446,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 81,446,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 81,446,1951
 
                            *** END OF RECORD ***