*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BU2680300
CHEMICAL NAME           : Amphotericin B, mixt. with
                          (3-alpha,5-beta,12-alpha)-3,12-dihydroxycholan-24-oic
                          acid monosodium salt
CAS REGISTRY NUMBER     : 58501-21-6
LAST UPDATED            : 199504
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C47-H73-N-O17.C24-H40-O4.Na
MOLECULAR WEIGHT        : 1339.84
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amphotericin B deoxycholate
   * Amphotericin B sodium desoxycholate
   * Desoxycholate amphotericin B
   * Fungizone intravenous
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 38,713,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 35,615,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg/28D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Blood - other changes
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 38,713,1994
 
                            *** END OF RECORD ***