*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TN3320000 CHEMICAL NAME : 1-Piperidinepropanol, 2-methyl-, benzoate(ester) CAS REGISTRY NUMBER : 32248-37-6 BEILSTEIN REFERENCE NO. : 0012274 REFERENCE : 5-20-04-00079 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C16-H23-N-O2 MOLECULAR WEIGHT : 261.40 WISWESSER LINE NOTATION : T6NTJ A3OVR& B1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 3-Benzoxy-1-(2-methylpiperidino)propane * Benzoyl-gamma-(2-methylpiperidino)propanol * Isocaine (iso-sol. Co.) base * 2-Methyl-1-piperidinopropanol, benzoate * (2-Methylpiperidino)propyl benzoate * gamma-(2-Methylpiperidyl)propyl benzoate * Metycaine * Neothesin * Piperocaine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 13,27,1956 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 590 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,4,1950 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 26400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,4,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,37,1952 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraspinal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 9500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 54,137,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 268 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - local anesthetic REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 1,305,1940 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraspinal SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 45,291,1932 *** END OF RECORD ***