*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TN6157500
CHEMICAL NAME           : Piperidinium,
                          1,1'-(1,4-piperazinediyldiethylene)bis(1-ethyl-,
                          diiodide
CAS REGISTRY NUMBER     : 4727-62-2
LAST UPDATED            : 198311
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H46-N4.2I
MOLECULAR WEIGHT        : 620.52
WISWESSER LINE NOTATION : T6N DNTJ A2- AT6KTJ A2& D2- AT6KTJ A2 &I 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 336 HC
   * 1,1'-(1,4-Piperazinediyldiethylene)bis(1-ethylpiperidinium iodide)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 9,314,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 94,1,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 7,368,1949
 
                            *** END OF RECORD ***