*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TN8990000
CHEMICAL NAME           : 4-Piperidinone, N-nitroso-
CAS REGISTRY NUMBER     : 55556-91-7
BEILSTEIN REFERENCE NO. : 0113762
REFERENCE               : 5-21-06-00429 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H8-N2-O2
MOLECULAR WEIGHT        : 128.15
WISWESSER LINE NOTATION : T6N DVTJ ANO
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Nitroso-4-piperidinone
   * Nitroso-4-piperidone
   * 4-Piperidone, 1-nitroso-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1640 mg/kg/36W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Liver - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   55,705,1975
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1725 mg/kg/30W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Liver - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,1351,1984
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   TCMUE9 Topics in Chemical Mutagenesis.  (Plenum Pub. Corp., 233 Spring
   Street, New York, NY 10013) V.1-    1984-  Volume(issue)/page/year:
   1,13,1984

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***