*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TO1183100
CHEMICAL NAME           : Piper longum L., ethanol extract
SUBSTANCE DEFINITION :
   Plant belonging to the family Piperaceae
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * FPL
   * Fructus piperis longi
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 87400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 3,17,1983
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   IJSIDW Indian Journal of Pharmaceutical Sciences.  (Kalina, Santa Cruz
   (East), Bombay 400 029, India)  V.40(2)-    1978-  Volume(issue)/page/year:
   40,113,1978
 
                            *** END OF RECORD ***