*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TO1575000
CHEMICAL NAME           : Piperonal
CAS REGISTRY NUMBER     : 120-57-0
LAST UPDATED            : 199710
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C8-H6-O3
MOLECULAR WEIGHT        : 150.14
WISWESSER LINE NOTATION : T56 BO DO CHJ GVH
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzaldehyde, 3,4-(methylenedioxy)-
   * 1,3-Benzodioxole-5-carboxaldehyde
   * 3,4-Dihydroxybenzaldehyde methylene ketal
   * Dioxymethylene-protocatechuic aldehyde
   * Heliotropin
   * Heliotropine
   * 3,4-Methylene-dihydroxybenzaldehyde
   * 3,4-Methylenedioxybenzaldehyde
   * Piperonaldehyde
   * Piperonyl aldehyde
   * Protocatechuic aldehyde methylene ether
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 100%
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 12,907,1974
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   6,378,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0535062
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   RMSRA6 Revue Medicale de la Suisse Romande.  (Societe Medicale de La Suisse
   Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland)  V.1-    1881-
   Volume(issue)/page/year: 16,449,1896
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,370,1954
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 120 ug/L
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 20,254,1986
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 2 mg
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 20,254,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83199
       No. of Facilities: 128 (estimated)
       No. of Industries: 7
       No. of Occupations: 37
       No. of Employees: 7982 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83199
       No. of Facilities: 6503 (estimated)
       No. of Industries: 46
       No. of Occupations: 77
       No. of Employees: 113433 (estimated)
       No. of Female Employees: 68861 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***