*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TO7700000
CHEMICAL NAME           : Pivalic acid
CAS REGISTRY NUMBER     : 75-98-9
BEILSTEIN REFERENCE NO. : 0969480
REFERENCE               : 4-02-00-00908 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C5-H10-O2
MOLECULAR WEIGHT        : 102.15
WISWESSER LINE NOTATION : QVX1&1&1
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Acetic acid, trimethyl-
   * 2,2-Dimethylpropanoic acid
   * alpha,alpha-Dimethylpropionic acid
   * 2,2-Dimethylpropionic acid
   * Kyselina 2,2-dimethylpropionova
   * Kyselina pivalova
   * Neopentanoic acid
   * tert-Pentanoic acid
   * Propionic acid, 2,2-dimethyl-
   * Trimethylacetic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 4,863,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 4,863,1978
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 188 mg/kg/47W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   17,61,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1178
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1683 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1178
       No. of Facilities: 16 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1462 (estimated)
       No. of Female Employees: 996 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***