*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2160000
CHEMICAL NAME           : Platinum
CAS REGISTRY NUMBER     : 7440-06-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 27
MOLECULAR FORMULA       : Pt
MOLECULAR WEIGHT        : 195.09
WISWESSER LINE NOTATION : .PT
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * C.I. 77795
   * Liquid bright platinum
   * Platin
   * Platinum
   * Platinum Black
   * Platinum sponge
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9100 mg/kg/26W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 23(9),4,1979
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5250 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   42,75,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 gm/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   42,75,1955

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 1 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.002 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,213,1971

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993
   
   OEL-BELGIUM:TWA 1 mg/m3 JAN 1993
   
   OEL-DENMARK:TWA 1 mg/m3 JAN 1993
   
   OEL-FRANCE:TWA 1 mg/m3 JAN 1993
   
   OEL-HUNGARY:TWA 0.001 mg/m3;STEL 0.002 mg/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 1 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO PLATINUM (as Pt), metal-air:10H TWA 1 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO PLATINUM (as Pt), soluble salts-air:10H TWA 0.002 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 60125
       No. of Facilities: 63 (estimated)
       No. of Industries: 3
       No. of Occupations: 4
       No. of Employees: 680 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X4385
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 28 (estimated)
       No. of Female Employees: 7 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5987
       No. of Facilities: 23 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 23 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7504
       No. of Facilities: 10 (estimated)
       No. of Industries: 2
       No. of Occupations: 1
       No. of Employees: 428 (estimated)
       No. of Female Employees: 407 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 60125
       No. of Facilities: 677 (estimated)
       No. of Industries: 16
       No. of Occupations: 26
       No. of Employees: 22935 (estimated)
       No. of Female Employees: 3498 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Elements by ICP, 7300
   
   NIOSH Analytical Method, 1994: Metals in urine, 8310
   
   NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005

 
                            *** END OF RECORD ***