*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2171500 CHEMICAL NAME : Platinum(II), (1,2-benzenediamine-N,N')dichloro-, (SP-4-2)- CAS REGISTRY NUMBER : 38780-39-1 LAST UPDATED : 199410 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C6-H8-Cl2-N2-Pt MOLECULAR WEIGHT : 374.15 WISWESSER LINE NOTATION : ZR BZ &G-PT-G -Z COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * cis-Dichloro(1,2-diaminobenzene)platinum(II) * cis-Dichloro(o-phenylenediamine)platinum (II) * Platinum(II), dichloro(o-phenylenediammine)-, (Z)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Tumorigenic - facilitates action of known carcinogen REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 11,145,1975 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 2300 nmol/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,459,1980 TYPE OF TEST : DNA inhibition TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 2500 nmol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 29,327,1980 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 5 umol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 29,327,1980 *** END OF RECORD ***