*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2275810
CHEMICAL NAME           : Platinum(II),
                          (cyclobutane-1,1-dicarboxylato)((R)-2-methyl-1,4-buta
                          nediammine)-, (Z)-
CAS REGISTRY NUMBER     : 110172-45-7
LAST UPDATED            : 199412
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H20-N2-O4-Pt
MOLECULAR WEIGHT        : 439.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   cis-1,1-Cyclobutanedicarboxylato-(2R)-2-methyl-1,4-butanediammineplatinu
     m(II)
   *   (Z)-(Cyclobutane-1,1-dicarboxylato)((R)-2-methyl-1,4-butanediammine)plat
     inum(II)
   * NK 121
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 29,339,1988
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 29,339,1988
 
                            *** END OF RECORD ***