*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2275818
CHEMICAL NAME           : Platinum,
                          (1,1-cyclobutanedicarboxylato(2-))(tetrahydro-4H-pyra
                          n-4,4-dimethanamine-N ,N')-, (SP-4-2)-
CAS REGISTRY NUMBER     : 111523-41-2
LAST UPDATED            : 199406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C13-H22-N2-O5-Pt
MOLECULAR WEIGHT        : 481.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CL 287110
   *   cis-(1,1-Cyclobutanedicarboxylato)(tetrahydro-4H-pyran-4,4-bis(methylami
     ne))platinum
   * Enloplatin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   17,459,1992
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   17,459,1992
 
                            *** END OF RECORD ***