*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2275840 CHEMICAL NAME : Platinum, (1,2-cyclohexanediamine-N,N')bis(neodecanoato-O)-, (SP-4-2-(1R-trans))- CAS REGISTRY NUMBER : 114488-24-3 LAST UPDATED : 199103 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C26-H52-N2-O4-Pt MOLECULAR WEIGHT : 651.89 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclo hexaneplatinum(II) * (1,2-Cyclohexanediamine-N,N')bis(neodecanoato-O)platinum (SP-4-2-(1R-trans)) * L-Nddp * Platinum, bis(neodecanoato)(trans-1,2-cyclohexanediammine)-, (Z)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60500 ug/kg TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - renal function tests depressed Blood - granulocytopenia REFERENCE : CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 24,1,1989 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Blood - hemorrhage Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 24,1,1989 *** END OF RECORD ***