*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2275940
CHEMICAL NAME           : Platinum(II),
                          (cyclohexane-1,2-diammine)bis(methanesulfanato-O-)-
CAS REGISTRY NUMBER     : 65285-86-1
LAST UPDATED            : 199107
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H20-N2-O6-Pt-S2
MOLECULAR WEIGHT        : 499.51
WISWESSER LINE NOTATION : L6TJ AZ BZ &WSO&1 2 &-PT-
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (1,2-Cyclohexanediamine-N,N')bis(methanesulfanato-O-) platinum
   * NSC-263158
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,201,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 61,1519,1977
 
                            *** END OF RECORD ***