*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2278000 CHEMICAL NAME : Platinum (II), (cyclohexane-1,2-diammine)malonato- CAS REGISTRY NUMBER : 52351-07-2 LAST UPDATED : 199803 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C9-H16-N2-O4-Pt MOLECULAR WEIGHT : 411.36 WISWESSER LINE NOTATION : L6TJ AZ BZ &QV1VQ &-PT- COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * JM 74 * Malonato-1,2-diaminocyclohexaneplatinum (II) * NSC-224,964 * PHM * Platinum, (1,2-cyclohexanediamine-N,N')(propanedioato(2-)-O,O')-, (SP-4-2)- * PT 174 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,377,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 60 mg/kg/5D-I TOXIC EFFECTS : Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB81-108912 ** MUTATION DATA ** TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5600 ug/kg REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,377,1986 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 65,315,1976 *** END OF RECORD ***