*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2278000
CHEMICAL NAME           : Platinum (II), (cyclohexane-1,2-diammine)malonato-
CAS REGISTRY NUMBER     : 52351-07-2
LAST UPDATED            : 199803
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C9-H16-N2-O4-Pt
MOLECULAR WEIGHT        : 411.36
WISWESSER LINE NOTATION : L6TJ AZ BZ &QV1VQ &-PT-
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * JM 74
   * Malonato-1,2-diaminocyclohexaneplatinum (II)
   * NSC-224,964
   * PHM
   * Platinum, (1,2-cyclohexanediamine-N,N')(propanedioato(2-)-O,O')-,  
   (SP-4-2)-
   * PT 174
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,377,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 60 mg/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Gastrointestinal - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-108912
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 5600 ug/kg
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,377,1986

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 65,315,1976

 
                            *** END OF RECORD ***