*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2280500 CHEMICAL NAME : Platinum, (1,2-cyclohexanediamine-N,N')(sulfato(2-)-O,O')-, (SP-4-2) CAS REGISTRY NUMBER : 61593-75-7 LAST UPDATED : 199803 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C6-H14-N2-O4-Pt-S MOLECULAR WEIGHT : 405.37 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * (Cyclohexane-1,2-diammine)sulfatoplatinum(II) * NSC 250,427 * PT 195 * Sulfato-1,2-diaminocyclohexaneplatinum(II) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,377,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 17(4),54,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 7500 ug/kg/5D-I TOXIC EFFECTS : Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB81-108912 ** MUTATION DATA ** TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 180 ug/kg REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,377,1986 *** END OF RECORD ***