*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2280500
CHEMICAL NAME           : Platinum,
                          (1,2-cyclohexanediamine-N,N')(sulfato(2-)-O,O')-,
                          (SP-4-2)
CAS REGISTRY NUMBER     : 61593-75-7
LAST UPDATED            : 199803
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H14-N2-O4-Pt-S
MOLECULAR WEIGHT        : 405.37
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * (Cyclohexane-1,2-diammine)sulfatoplatinum(II)
   * NSC 250,427
   * PT 195
   * Sulfato-1,2-diaminocyclohexaneplatinum(II)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,377,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,    1978-88. For
   publisher information, see ZYZAEU.  Volume(issue)/page/year: 17(4),54,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7500 ug/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Gastrointestinal - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-108912
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 180 ug/kg
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,377,1986
 
                            *** END OF RECORD ***