*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2494900 CHEMICAL NAME : Platinum(II), dichloro(4,5-dimethyl-o-phenylenediammine)-, (SP-4-2)- CAS REGISTRY NUMBER : 40580-75-4 LAST UPDATED : 199410 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C8-H12-Cl2-N2-Pt MOLECULAR WEIGHT : 402.21 WISWESSER LINE NOTATION : ZR BZ D1 E1 &G-PT-G COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * cis-Dichloro(4,5-dimethyl-o-phenylenediammine)platinum (II) * Platinum (II), dichloro(4,5-dimethyl-o-phenylenediammine) (Z)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 283 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Tumorigenic - active as anti-cancer agent REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 11,145,1975 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10200 nmol/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,459,1980 *** END OF RECORD ***