*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2497100
CHEMICAL NAME           : Platinum(II), dichloro(ethylenediammine)-, (SP-4-2)-
CAS REGISTRY NUMBER     : 14096-51-6
LAST UPDATED            : 199410
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C2-H8-Cl2-N2-Pt
MOLECULAR WEIGHT        : 326.11
WISWESSER LINE NOTATION : Z2Z &G-PT-G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * cis-Dichloroethylenediamineplatinum(II)
   * Platinum, dichloro(1,2-ethanediamine-N,N')-, (SP-4-2)-
   * Platinum, dichloro(ethylenediammine)-, cis-
   * Pt-05
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BICHBX Bioinorganic Chemistry.  (New York, NY)  V.1-9, 1971-78.
   Volume(issue)/page/year: 2,187,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,45,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 33 umol/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 34,379,1987
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   16,39,1977
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 90,209,1979
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 25 umol/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 6,207,1970
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 25 umol/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 6,207,1970
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   10,27,1975
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   23,1659,1974
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   23,1659,1974
 
                            *** END OF RECORD ***