*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2497600 CHEMICAL NAME : Platinum, dimethylbis(sulfinylbis(methane)-S)-, (SP-4-2)- CAS REGISTRY NUMBER : 70423-98-2 LAST UPDATED : 199409 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H18-O2-Pt-S2 MOLECULAR WEIGHT : 381.45 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Dimethylbis(sulfinylbis(methane)-S)platinum (SP-4-2) * cis-Dimethylbis(sulfinylbis(methane)-S)platinum *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 46400 ug/kg TOXIC EFFECTS : Liver - other changes REFERENCE : ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990- Volume(issue)/page/year: 3,9,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 51200 ug/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990- Volume(issue)/page/year: 3,9,1992 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990- Volume(issue)/page/year: 3,9,1992 *** END OF RECORD ***