*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2497600
CHEMICAL NAME           : Platinum, dimethylbis(sulfinylbis(methane)-S)-,
                          (SP-4-2)-
CAS REGISTRY NUMBER     : 70423-98-2
LAST UPDATED            : 199409
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C6-H18-O2-Pt-S2
MOLECULAR WEIGHT        : 381.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dimethylbis(sulfinylbis(methane)-S)platinum (SP-4-2)
   * cis-Dimethylbis(sulfinylbis(methane)-S)platinum
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 46400 ug/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   ANTDEV Anti-Cancer Drugs.  (Rapid Communications of Oxford Ltd., The Old
   Malthous, Paradise St., Oxford OX1 1LD, UK)  V.1-    1990-
   Volume(issue)/page/year: 3,9,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51200 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ANTDEV Anti-Cancer Drugs.  (Rapid Communications of Oxford Ltd., The Old
   Malthous, Paradise St., Oxford OX1 1LD, UK)  V.1-    1990-
   Volume(issue)/page/year: 3,9,1992
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ANTDEV Anti-Cancer Drugs.  (Rapid Communications of Oxford Ltd., The Old
   Malthous, Paradise St., Oxford OX1 1LD, UK)  V.1-    1990-
   Volume(issue)/page/year: 3,9,1992
 
                            *** END OF RECORD ***