*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2505500
CHEMICAL NAME           : Platinum (II), (ethylenediammine)malonato-
CAS REGISTRY NUMBER     : 41666-77-7
OTHER CAS REGISTRY NOS. : 77641-64-6
LAST UPDATED            : 199509
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C5-H10-N2-O4-Pt
MOLECULAR WEIGHT        : 357.26
WISWESSER LINE NOTATION : Z2Z &QV1VQ &-PT-
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * (Ethylenediammine)malonatoplatinum(II)
   * Ethylenediamine platinum(II) malonate
   * JM-40
   * Malpen
   * NSC 146068
   * Platinum, (1,2-ethanediamine-N,N')(propanedioato(2-)-O,O')-, (SP-4-2)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1080 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,2148,1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BICHBX Bioinorganic Chemistry.  (New York, NY)  V.1-9, 1971-78.
   Volume(issue)/page/year: 2,187,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,2148,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 120 mg/kg/5D-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB80-217292
 
                            *** END OF RECORD ***