*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2505900
CHEMICAL NAME           : Platinum,
                          (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,
                          N')(propanedioato(2-) -O,O')-,
                          (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-
CAS REGISTRY NUMBER     : 146665-77-2
LAST UPDATED            : 199509
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C11-H20-N2-O6-Pt
MOLECULAR WEIGHT        : 471.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   cis-Malonato((4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane)plat
     inum(II)
   * NSC D644591
   * SKI 2053R
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1590 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 198 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 235 mg/kg/13W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - changes in leukocyte (WBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,217,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 15 mg/kg/90D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Related to Chronic Data - death
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,235,1992
 
                            *** END OF RECORD ***