*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP2518000 CHEMICAL NAME : Platyphylline CAS REGISTRY NUMBER : 480-78-4 LAST UPDATED : 199801 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H27-N-O5 MOLECULAR WEIGHT : 337.46 COMPOUND DESCRIPTOR : Drug Mutagen Natural Product SYNONYMS/TRADE NAMES : * (1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione * Platiphillin * Platiphyllin * Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3100 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 252 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 46,493,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - lymphoma, including Hodgkin's disease REFERENCE : RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued. Volume(issue)/page/year: 5,53,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2573 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 577 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - lymphoma, including Hodgkin's disease REFERENCE : RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued. Volume(issue)/page/year: 5,53,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5700 mg/kg/19D-I TOXIC EFFECTS : Liver - liver function tests impaired Related to Chronic Data - death REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal *** END OF RECORD ***