*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2518000
CHEMICAL NAME           : Platyphylline
CAS REGISTRY NUMBER     : 480-78-4
LAST UPDATED            : 199801
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C18-H27-N-O5
MOLECULAR WEIGHT        : 337.46
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * (1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
   * Platiphillin
   * Platiphyllin
   * Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (1),34,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 252 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJEBAK Australian Journal of Experimental Biology and Medical Science.
   (Adelaide, S.A., Australia) V.1-64, 1924-86.  Volume(issue)/page/year:
   46,493,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   RETOAE Research Today.  (Indianapolis, IN)  V.1-16, 1944-60.  Discontinued.
   Volume(issue)/page/year: 5,53,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2573 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (1),34,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 577 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (1),34,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   RETOAE Research Today.  (Indianapolis, IN)  V.1-16, 1944-60.  Discontinued.
   Volume(issue)/page/year: 5,53,1949
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5700 mg/kg/19D-I
TOXIC EFFECTS :
   Liver - liver function tests impaired
   Related to Chronic Data - death
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (1),34,1997

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***