*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2519100
CHEMICAL NAME           : Platyphylline hydrochloride
CAS REGISTRY NUMBER     : 66641-38-1
LAST UPDATED            : 198806
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C18-H27-N-O5.Cl-H
MOLECULAR WEIGHT        : 373.92
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Platiphillin hydrochloride
   * Platiphyllin hydrochloride
   * Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, hydrochloride,  
   (1-alpha)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Vascular - other changes
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   FRBGAT Frontiers of Biology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1966- Volume(issue)/page/year:
   9,142,1968
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 68,130,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 68,130,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 68,130,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 68,130,1940
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ZEVBA5 Zeitschrift fuer Vererbungslehre.  (Berlin, Fed. Rep. Ger.) V.89-98,
   1958-66.  For publisher information, see MGGEAE. Volume(issue)/page/year:
   91,74,1960
 
                            *** END OF RECORD ***