*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP4725000 CHEMICAL NAME : Plumbane, tetramethyl- CAS REGISTRY NUMBER : 75-74-1 BEILSTEIN REFERENCE NO. : 3902986 REFERENCE : 4-04-00-04348 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 58 MOLECULAR FORMULA : C4-H12-Pb MOLECULAR WEIGHT : 267.35 WISWESSER LINE NOTATION : 1-PB-1&1&1 COMPOUND DESCRIPTOR : Organometallic Reproductive Effector SYNONYMS/TRADE NAMES : * Lead, tetramethyl- * Piombo tetra-metile * Tetramethyl lead * Tetramethylolovo * Tetramethylplumbane * TML *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- Volume(issue)/page/year: 54,486,1963 TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >9840 mg/m3/1H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 18,277,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- Volume(issue)/page/year: 54,486,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 88 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- Volume(issue)/page/year: 54,486,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 3,226,1961 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8500 mg/m3/30M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1258,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 15,3,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3391 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 15,3,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 38,161,1930 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 109 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,455,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/m3/1H/5D-I TOXIC EFFECTS : Brain and Coverings - other degenerative changes Behavioral - irritability Lungs, Thorax, or Respiration - other changes REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533656-1 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 42 mg/kg/7D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,187,1978 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 112 mg/kg SEX/DURATION : female 9-11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,265,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 80 mg/kg SEX/DURATION : female 9-11 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,265,1972 *** REVIEWS *** ACGIH TLV-TWA 0.15 mg(Pb)/m3, monitoring (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pb,255,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.15 mg(Pb)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,253,1971 OSHA PEL (Gen Indu):8H TWA 0.075 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.15 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.15 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.075 mg(Pb)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.05 mg(Pb)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.15 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 0.01 ppm (0.075 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-BELGIUM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-BELGIUM:TWA 0.15 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.007 ppm (0.05 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FINLAND:TWA 0.075 mg/m3;STEL 0.23 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FRANCE:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-FRANCE:TWA 0.15 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.075 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-HUNGARY:STEL 0.04 mg(Pb)/m3;Carcinogen JAN 1993 OEL-HUNGARY:TWA 0.005 mg/m3;STEL 0.01 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.15 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.07 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-RUSSIA:STEL 0.005 ppm (0.01 mg(Pb)/m3) JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Pb)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 0.05 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Pb)/m3 (total dust) JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.075 mg/m3);STEL 0.02 ppm;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-THAILAND:TWA 0.07 mg/m3 JAN 1993 OEL-THAILAND:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRAMETHYLLEAD-air:10H TWA 0.075 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71860 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH Analytical Method, 1994: Tetramethyl lead (as Pb), 2534 *** END OF RECORD ***