*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP8640000 CHEMICAL NAME : 8-beta-Podocarpane-delta(sup 13,alpha)-acetic acid, 3-beta-hydroxy-14-alpha-methyl-7-oxo-, 2-(dimethylamino)ethyl ester, hydrochloride, (E)- CAS REGISTRY NUMBER : 33445-03-3 LAST UPDATED : 198605 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C24-H39-N-O4.Cl-H MOLECULAR WEIGHT : 442.10 WISWESSER LINE NOTATION : L B666 EY HVTJ A1 EU1VO2N1&1 F1 K1 K1 LQ &GH SYNONYMS/TRADE NAMES : * Cassaine hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 400 ug/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) Lungs, Thorax, or Respiration - other changes REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,582,1967 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 806 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,9,1938 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2640 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 13,35,1976 *** END OF RECORD ***