*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP8640000
CHEMICAL NAME           : 8-beta-Podocarpane-delta(sup 13,alpha)-acetic acid,
                          3-beta-hydroxy-14-alpha-methyl-7-oxo-,
                          2-(dimethylamino)ethyl ester, hydrochloride, (E)-
CAS REGISTRY NUMBER     : 33445-03-3
LAST UPDATED            : 198605
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H39-N-O4.Cl-H
MOLECULAR WEIGHT        : 442.10
WISWESSER LINE NOTATION : L B666 EY HVTJ A1 EU1VO2N1&1 F1 K1 K1 LQ &GH
SYNONYMS/TRADE NAMES :
   * Cassaine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 10,582,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 806 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPHAA3 Journal of the American Pharmaceutical Association.  (Washington, DC)
    V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year:
   27,9,1938
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2640 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APSXAS Acta Pharmaceutica Suecica.  (Apotekarsocieteten-Farmacevtiska
   Foereningen, Box 1136, S-111, 81 Stockholm, Sweden)  V.1-    1964-
   Volume(issue)/page/year: 13,35,1976
 
                            *** END OF RECORD ***