*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TR0350000 CHEMICAL NAME : Polymethylenepolyphenyl isocyanate CAS REGISTRY NUMBER : 9016-87-9 OTHER CAS REGISTRY NOS. : 39278-75-6 66174-31-0 LAST UPDATED : 199710 DATA ITEMS CITED : 15 COMPOUND DESCRIPTOR : Tumorigen Primary Irritant SYNONYMS/TRADE NAMES : * Coronate MR 200 * CR 200 * Desmodur PU 1520A20 * Desmodur 44V20 * E 534 * Isobind 100 * Isocyanate 580 * Isonate 390P * Isoset CX 11 * Kaiser NCO 20 * Lupranate M 10 * Lupranate M 70 * Lupranate M 20S * Luprinate M 20 * MDI-CR * MDI-CR 100 * MDI-CR 200 * MDI-CR 300 * Millionate 300 * Millionate MR * Millionate MR 100 * Millionate MR 200 * Millionate MR 300 * Millionate MR 340 * Millionate MR 400 * Millionate MR 500 * Mobay MRS * Mondur E 429 * Mondur E 441 * Mondur E 541 * Mondur MR * Mondur MR 200 * Mondur MRS * Mondur MRS 10 * MR 200 * MR 2000 * NCO 20 * Niax AFPI * PAPI * PAPI 20 * PAPI 27 * PAPI 135 * PAPI 580 * PAPI 901 * Polymeric diphenyl methylene diisocyanate * Rubinate M * Rubinate MF 178 * Rubinate MF 182 * Sumidur 44V10 * Sumidur 44V20 * Sumidur 44VM * Suprasec 1042 * Suprasec DC * Systanate MR * Systanat MR * Takenate 300C * Tedimon 31 * Thanate P 210 * Thanate P 220 * Thanate P 270 *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg REACTION SEVERITY : Mild REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 49 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 490 mg/m3/4H TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory depression Blood - hemorrhage REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555284 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >9400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0517028 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/m3/2W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12 mg/m3/13W-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 ** TUMORIGENIC DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mg/m3/6H/2Y-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84716 No. of Facilities: 367 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 2795 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84716 No. of Facilities: 2951 (estimated) No. of Industries: 59 No. of Occupations: 48 No. of Employees: 45703 (estimated) No. of Female Employees: 6250 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***