*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TR0350000
CHEMICAL NAME           : Polymethylenepolyphenyl isocyanate
CAS REGISTRY NUMBER     : 9016-87-9
OTHER CAS REGISTRY NOS. : 39278-75-6
                          66174-31-0
LAST UPDATED            : 199710
DATA ITEMS CITED        : 15
COMPOUND DESCRIPTOR     : Tumorigen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Coronate MR 200
   * CR 200
   * Desmodur PU 1520A20
   * Desmodur 44V20
   * E 534
   * Isobind 100
   * Isocyanate 580
   * Isonate 390P
   * Isoset CX 11
   * Kaiser NCO 20
   * Lupranate M 10
   * Lupranate M 70
   * Lupranate M 20S
   * Luprinate M 20
   * MDI-CR
   * MDI-CR 100
   * MDI-CR 200
   * MDI-CR 300
   * Millionate 300
   * Millionate MR
   * Millionate MR 100
   * Millionate MR 200
   * Millionate MR 300
   * Millionate MR 340
   * Millionate MR 400
   * Millionate MR 500
   * Mobay MRS
   * Mondur E 429
   * Mondur E 441
   * Mondur E 541
   * Mondur MR
   * Mondur MR 200
   * Mondur MRS
   * Mondur MRS 10
   * MR 200
   * MR 2000
   * NCO 20
   * Niax AFPI
   * PAPI
   * PAPI 20
   * PAPI 27
   * PAPI 135
   * PAPI 580
   * PAPI 901
   * Polymeric diphenyl methylene diisocyanate
   * Rubinate M
   * Rubinate MF 178
   * Rubinate MF 182
   * Sumidur 44V10
   * Sumidur 44V20
   * Sumidur 44VM
   * Suprasec 1042
   * Suprasec DC
   * Systanate MR
   * Systanat MR
   * Takenate 300C
   * Tedimon 31
   * Thanate P 210
   * Thanate P 220
   * Thanate P 270
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Mild
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0516728
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 49 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0516728
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 490 mg/m3/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - respiratory depression
   Blood - hemorrhage
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0555284
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >9400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS0517028
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/m3/2W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0525557
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 mg/m3/13W-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0525557
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6 mg/m3/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0525557

                              *** REVIEWS ***
 
   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 19,303,1979

   IARC Cancer Review:Animal No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 19,303,1979

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84716
       No. of Facilities: 367 (estimated)
       No. of Industries: 10
       No. of Occupations: 14
       No. of Employees: 2795 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84716
       No. of Facilities: 2951 (estimated)
       No. of Industries: 59
       No. of Occupations: 48
       No. of Employees: 45703 (estimated)
       No. of Female Employees: 6250 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***