*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TP9002050 CHEMICAL NAME : Podophyllotoxin, 4,6-O-benzylidene-beta-D-glucopyranoside CAS REGISTRY NUMBER : 16481-54-2 LAST UPDATED : 199012 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C28-H32-O13 MOLECULAR WEIGHT : 576.60 WISWESSER LINE NOTATION : T E5 C665 FVO NO PO OHTT&&J DR CO1 DO1 EO1& JO- HT66 BO DO GOTJ CR& IQ JQ COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 4,6-O-Benzylide-beta-D-glucopyranosidepodophyllotoxin * PGB * Podophyllotoxin-beta-D-benzylidene glucoside * Podophyllotoxin glucoside * SP-G Iia *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 340 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969 ** MUTATION DATA ** TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 30 mg/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2998,1977 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 30 mg/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2998,1977 *** END OF RECORD ***