*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TR8100000
CHEMICAL NAME : Polyvinyl alcohol
CAS REGISTRY NUMBER : 9002-89-5
LAST UPDATED : 199712
DATA ITEMS CITED : 16
MOLECULAR FORMULA : (C2-H4-O)x
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Alcotex 88/05
* Alcotex 88/10
* Alkotex
* Alvyl
* Aracet APV
* Cipoviol W 72
* Covol
* Covol 971
* Elvanol
* Elvanol 50-42
* Elvanol 52-22
* Elvanol 70-05
* Elvanol 71-30
* Elvanol 90-50
* Elvanol 522-22
* Elvanol 73125G
* EP 160
* Ethenol homopolymer
* Galvatol 1-60
* Gelvatol
* Gelvatol 1-30
* Gelvatol 1-90
* Gelvatol 3-91
* Gelvatol 20-30
* Gelvatol 2090
* GH 20
* GL 02
* GL 03
* GLO 5
* GM 14
* Gohsenol
* Gohsenol AH 22
* Gohsenol GH
* Gohsenol GH 17
* Gohsenol GH 20
* Gohsenol GH 23
* Gohsenol GL 03
* Gohsenol GL 05
* Gohsenol GL 08
* Gohsenol GM 14
* Gohsenol GM 94
* Gohsenol GM 14L
* Gohsenol KH 17
* Gohsenol NH 05
* Gohsenol NH 17
* Gohsenol NH 18
* Gohsenol NH 20
* Gohsenol NH 26
* Gohsenol NK 114
* Gohsenol NL 05
* Gohsenol NM 14
* Ivalon
* Kuralon VP
* Kurare poval 1700
* Kurare PVA 205
* Kurate poval 120
* Lemol
* Lemol 5-88
* Lemol 5-98
* Lemol 12-88
* Lemol 16-98
* Lemol 24-98
* Lemol 30-98
* Lemol 51-98
* Lemol 60-98
* Lemol 75-98
* Lemol GF-60
* M 13/20
* Mowiol
* Mowiol N 30-88
* Mowiol N 50-98
* Mowiol N 70-98
* NH 18
* NM 11
* NM 14
* Polydesis
* Polysizer 173
* Polyvinol
* Polyviol
* Polyviol M 13/140
* Polyviol MO 5/140
* Polyviol W 25/140
* Polyviol W 40/140
* Poval 117
* Poval 120
* Poval 203
* Poval 205
* Poval 217
* Poval 1700
* Poval C 17
* PVA 008
* PVS 4
* Resistoflex
* Rhodoviol
* Rhodoviol 4/125
* Rhodoviol 16/200
* Rhodoviol 4-125P
* Rhodoviol R 16/20
* Solvar
* Sumitex H 10
* Vibatex S
* Vinacol MH
* Vinalak
* Vinarol
* Vinarol DT
* Vinarole
* Vinarol ST
* Vinavilol 2-98
* Vinnarol
* Vinol
* Vinol 125
* Vinol 205
* Vinol 351
* Vinol 523
* Vinol unisize
* Vinyl alcohol polymer
* Vinylon film 2000
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >20 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(10),75,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14700 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(10),75,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22500 mg/kg/45D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(10),75,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45 mg/m3/2H/15D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 5,136,1963
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For
publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Immunological Including Allergic - increase in cellular immune response
REFERENCE :
BJSUAM British Journal of Surgery. (Quadrant Subscription Services Ltd.,
Oakfield House, Perrymount Rd., Haywards Heath, W. Sussex RH16 3DH, UK) V.1-
1913- Volume(issue)/page/year: 52,49,1965
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3768 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 19,424,1963
*** REVIEWS ***
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 19,341,1979
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 19,341,1979
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New
York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81944
No. of Facilities: 17615 (estimated)
No. of Industries: 159
No. of Occupations: 98
No. of Employees: 124708 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8571
No. of Facilities: 25435 (estimated)
No. of Industries: 181
No. of Occupations: 133
No. of Employees: 500947 (estimated)
No. of Female Employees: 183064 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis studies; test completed (post peer review), October 1997
*** END OF RECORD ***