*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TS5500000
CHEMICAL NAME           : 2,18-Porphinedipropionic acid,
                          7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
CAS REGISTRY NUMBER     : 14459-29-1
BEILSTEIN REFERENCE NO. : 0078957
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C34-H38-N4-O6
MOLECULAR WEIGHT        : 598.76
WISWESSER LINE NOTATION : T D5 I5 N5-16-5 A D- I- N- AM D-N I-M N-NJ EYQ F J
                          K2VQ O2VQ TYQ U
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Hematoporphyrin
   * HP
   * Photodyn
   * 1,3,5,8-Tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionic  
   acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 307 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   57,219,1961
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 67,183,1981
 
                            *** END OF RECORD ***