*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TU4154090
CHEMICAL NAME : Pregna-1,4-diene-3,11,20-trione,
17,21-dihydroxy-16-beta-methyl-
CAS REGISTRY NUMBER : 1247-42-3
LAST UPDATED : 198910
DATA ITEMS CITED : 2
MOLECULAR FORMULA : C22-H28-O5
MOLECULAR WEIGHT : 372.50
WISWESSER LINE NOTATION : L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1
COMPOUND DESCRIPTOR : Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Betalone
* Betanisona
* Betapar
* Betapred
* Bitanisone
* Deltacortene beta
* Deltisona B
* Lepicortin-beta
* Meprednisone
* 16-beta-Methylprednisone
* 16-beta-Metilprednisone
* Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16-beta)-
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 14 mg/kg
SEX/DURATION : female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 6250 ug/kg
SEX/DURATION : female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977
*** END OF RECORD ***