*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5023000
CHEMICAL NAME           : Pregn-4-ene-3,20-dione,
                          11-beta,18-epoxy-18,21-dihydroxy-
CAS REGISTRY NUMBER     : 6251-69-0
LAST UPDATED            : 199703
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H28-O5
MOLECULAR WEIGHT        : 360.49
WISWESSER LINE NOTATION : T5 G6 F66 B5 A DO JV KUTJ CQ G1 SV1Q
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Aldosterone
   * 11-beta,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
   * 3,20-Diketo-11-beta,18-oxido-4-pregnene-18,21-diol
   * 11-beta-18-Epoxy-18,21-dihydroxypregn-4-ene-3,20-dione
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 ug/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JCINAO Journal of Clinical Investigation.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1924-  Volume(issue)/page/year:
   41,710,1962
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996
 
                            *** END OF RECORD ***