*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5559900
CHEMICAL NAME           : Pregn-4-en-3-one, 20-alpha-hydroxy-
CAS REGISTRY NUMBER     : 145-14-2
BEILSTEIN REFERENCE NO. : 2220567
REFERENCE               : 4-08-00-01018 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H32-O2
MOLECULAR WEIGHT        : 316.53
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * 20-alpha-Dihydroprogesterone
   * 20-alpha-Hydroxydihydroprogesterone
   * (20S)-20-Hydroxypregn-4-en-3-one
   * 20(S)-Hydroxyprogesterone
   * 20-alpha-Hydroxyprogesterone
   * Pregn-4-en-3-one, 20-hydroxy-, (20S)-
   * 20-alpha-Progerol
   * Progesterol-20-alpha
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 23,196,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 127,151,1977
 
                            *** END OF RECORD ***