*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TW3578700 CHEMICAL NAME : L-Prolinamide, N-((6-methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-hist idyl-, (3R-cis)- CAS REGISTRY NUMBER : 90243-66-6 LAST UPDATED : 199803 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C17-H24-N6-O4-S MOLECULAR WEIGHT : 408.53 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * CG 3703 * CNK-603 * CNK 602A * (-)-N-(((3R,6S)-6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L- prolinamide * (3R-cis)-N-((6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-pro linamide * Montirelin * NS 3 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4877784 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 2),165,1995 *** END OF RECORD ***