*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TW3578700
CHEMICAL NAME           : L-Prolinamide,
                          N-((6-methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-hist
                          idyl-, (3R-cis)-
CAS REGISTRY NUMBER     : 90243-66-6
LAST UPDATED            : 199803
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H24-N6-O4-S
MOLECULAR WEIGHT        : 408.53
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CG 3703
   * CNK-603
   * CNK 602A
   *   (-)-N-(((3R,6S)-6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-
     prolinamide
   *   (3R-cis)-N-((6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-pro
     linamide
   * Montirelin
   * NS 3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4877784
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 20(Suppl
   2),165,1995
 
                            *** END OF RECORD ***