*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TW3588900
CHEMICAL NAME           : L-Proline, 1-(N-(8-amino-1-carboxyoctyl)-L-alanyl)-,
                          (S)-
CAS REGISTRY NUMBER     : 120008-53-9
BEILSTEIN REFERENCE NO. : 3596741
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H31-N3-O5
MOLECULAR WEIGHT        : 357.51
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AB 47
   * N-(8-Amino-1(S)-carboxyoctyl)-L-alanyl-L-proline
   * (S)-1-(N-(8-Amino-1-carboxyoctyl)-L-alanyl)-L-proline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 42,1430,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1120 mg/kg/4W-C
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 42,1430,1992
 
                            *** END OF RECORD ***