*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TW4000000
CHEMICAL NAME           : L-Proline, 5-oxo-, monosodium salt
CAS REGISTRY NUMBER     : 28874-51-3
LAST UPDATED            : 199504
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C5-H7-N-O3.Na
MOLECULAR WEIGHT        : 152.12
SYNONYMS/TRADE NAMES :
   * Ajidew N-50
   * 5-Oxo-L-proline monosodium salt
   * Proline, 5-oxo-, monosodium salt, L-
   * Sodium L-pyroglutamate
   * Sodium L-pyrrolidonecarboxylate
   * Sodium pyrrolidone-5-carboxylate
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 gm/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,717,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 690 gm/kg/26W-C
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Liver - changes in liver weight
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,717,1992

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X2456
       No. of Facilities: 190 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 4559 (estimated)
       No. of Female Employees: 3989 (estimated)

 
                            *** END OF RECORD ***