*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX6850000
CHEMICAL NAME           : 1,3-Propanediamine,
                          N'-9-acridinyl-N,N-bis(2-chloroethyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 38915-00-3
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H23-Cl2-N3.2Cl-H
MOLECULAR WEIGHT        : 449.28
WISWESSER LINE NOTATION : T C666 BNJ IM3N2G2G &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acridine, 9-((3-(bis(2-chloroethyl)amino)propyl)amino)-, dihydrochloride
   * 9-((3-(Bis(2-chloroethyl)amino)propyl)amino)acridine dihydrochloride
   * ICR 220
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 449 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4875,1979
 
                            *** END OF RECORD ***