*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX7032250
CHEMICAL NAME           : 1,3-Propanediamine, N,N'-bis(3-(ethylamino)propyl)-
CAS REGISTRY NUMBER     : 121749-39-1
LAST UPDATED            : 199510
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C13-H32-N4
MOLECULAR WEIGHT        : 244.49
SYNONYMS/TRADE NAMES :
   * N,N'-Bis(3-(ethylamino)propyl)-1,3-propanediamine
   * N(sup 1),N(sup 11)-Bis(ethyl)norspermine
   * Denspm
   * N(sup 1),N(sup 11)-Diethylnorspermine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTDEV Anti-Cancer Drugs.  (Rapid Communications of Oxford Ltd., The Old
   Malthous, Paradise St., Oxford OX1 1LD, UK)  V.1-    1990-
   Volume(issue)/page/year: 5,448,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 325 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 37,3464,1994
 
                            *** END OF RECORD ***