*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TX7037500 CHEMICAL NAME : 1,3-Propanediamine, N-(2-chloroethyl)-N'-(7-chloro-2-methoxybenzo(b)-1,5- naphthyridin-10- yl)-, dihydrochloride, hydrate CAS REGISTRY NUMBER : 36167-69-8 OTHER CAS REGISTRY NOS. : 12798-09-3 LAST UPDATED : 199410 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H20-Cl2-N4-O.2Cl-H.H2-O MOLECULAR WEIGHT : 469.25 WISWESSER LINE NOTATION : T C666 BN GNJ FO1 IM3M2G MG &GH 2 &QH COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * ICR 372 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD20 - Lethal Dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,739,1972 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,739,1972 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 5 ug/plate REFERENCE : GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916- Volume(issue)/page/year: 78,823,1974 TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 1 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,506,1978 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test *** END OF RECORD ***