*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX7388500
CHEMICAL NAME           : 1,3-Propanediamine,
                          N,N-diethyl-N'-(6-methyl-5H-pyrido(3',4':4,5)pyrrolo(
                          2,3-g) isoquinolin-10-yl)-
CAS REGISTRY NUMBER     : 65222-35-7
BEILSTEIN REFERENCE NO. : 0571979
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H27-N5
MOLECULAR WEIGHT        : 361.54
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   10-((3-(Diethylamino)propyl)amino)-6-methyl-5H-pyrido(3',4':4,5)pyrrolo(
     2,3-g)isoquinoline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,181,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,1404,1988
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 17 umol/L
REFERENCE :
   BUCABS Bulletin du Cancer.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-
   1966-  Volume(issue)/page/year: 67,9,1980
 
                            *** END OF RECORD ***