*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX8040000
CHEMICAL NAME           : 1,3-Propanediamine,
                          N-hexyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 77280-91-2
LAST UPDATED            : 199509
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C22-H28-N4-O2.2Cl-H
MOLECULAR WEIGHT        : 453.46
WISWESSER LINE NOTATION : T C666 BNJ GNW IM3M6 &GH 2
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Acridine, 9-((3-(hexylamino)propyl)amino)-1-nitro-, dihydrochloride
   * C 1006
   * 9-((3-(Hexylamino)propyl)amino)-1-nitroacridine dihydrochloride
   * 1-Nitro-9-(3-hexylaminopropylamino)acridine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3820 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   30,385,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 10500 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,777,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 2500 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   49,311,1984
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   49,311,1984
 
TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse HeLa cell
DOSE/DURATION           : 44 mg/kg
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   38,1301,1989
 
                            *** END OF RECORD ***