*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TY2900000
CHEMICAL NAME           : 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
CAS REGISTRY NUMBER     : 77-86-1
OTHER CAS REGISTRY NOS. : 25149-07-9
                          108195-86-4
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C4-H11-N-O3
MOLECULAR WEIGHT        : 121.16
WISWESSER LINE NOTATION : Q1XZ1Q1Q
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Addex-tham
   * 2-Amino-2-(hydroxymethyl)propane-1,3-diol
   * 2-Amino-2-(hydroxymethyl)-1,3-propanediol
   * 2-Amino-2-methylol-1,3-propanediol
   * Aminotrimethylolmethane
   * Aminotris(hydroxymethyl)methane
   * Methylamine, 1,1,1-tris(hydroxymethyl)-
   * Pehanorm
   * Talatrol
   * THAM-E
   * THAM set
   * Trimethylolaminomethane
   * Tris (buffering agent)
   * Trisamine
   * Tris-amino
   * Trisaminol
   * Tris buffer
   * Tris-hydroxymethyl-aminomethan
   * Tris-hydroxymethylaminomethane
   * Tris(hydroxymethyl)methanamine
   * Tris(hydroxymethyl)methylamine
   * Trispuffer
   * Tris-steril
   * Trometamol
   * Trometamole
   * Tromethamine
   * Tromethane
   * Tromethanmin
   * Tutofusin tris
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   110,653,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,419,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   17,217,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - coma
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 22,315,1940

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81165
       No. of Facilities: 850 (estimated)
       No. of Industries: 4
       No. of Occupations: 6
       No. of Employees: 7274 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81165
       No. of Facilities: 2296 (estimated)
       No. of Industries: 9
       No. of Occupations: 22
       No. of Employees: 40897 (estimated)
       No. of Female Employees: 30773 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***