*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TY8400000
CHEMICAL NAME : 1,2-Propanediol, 3-(o-methoxyphenoxy)-
CAS REGISTRY NUMBER : 93-14-1
BEILSTEIN REFERENCE NO. : 2049375
REFERENCE : 4-06-00-05576 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C10-H14-O4
MOLECULAR WEIGHT : 198.24
WISWESSER LINE NOTATION : Q1YQ1OR BO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Aresol
* Cortussin
* Creson
* 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane
* Dilyn
* 2-G
* G 87
* Gaiamar
* GGE
* GGG
* Glycerin guaiacolate
* Glycerinmonoguaiacol ether
* Glycero-guaiacol ether
* Glycerol guaiacolate
* Glycerol-alpha-guajakolether
* Glycerol alpha-(o-methoxyphenyl)ether
* Glycerol-alpha-monoguaiacol ether
* Glycerol mono(2-methoxyphenyl)ether
* Glyceryl guaiacolate
* alpha-Glyceryl guaiacolate ether
* Glyceryl guaiacyl ether
* Glycotuss
* Gnaifenesin
* Guajacol-glycerinaether
* Guaiacolglicerinetere
* Guaiacol glyceryl ether
* Guaiacurane
* Guaiacyl glyceryl ether
* Guaiamar
* Guaianesin
* Guaifenesin
* Guaiphenesine
* Guaiphesin
* Guajacol-alpha-glycerinether
* Guajacuran
* Guajamar
* Guanar
* Guayanesin
* Guiaphenesin
* Hustosil
* Metfenossidiolo
* Methoxypropanediol
* 3-o-Methoxyphenoxypropane 1:2-diol
* 3-(o-Methoxyphenoxy)-1,2-propanediol
* 3-(2-Methoxyphenoxy)-1,2-propanediol
* o-Methoxyphenyl glyceryl ether
* Methphenoxydiol
* Metossipropandiolo
* Miocurin
* Miorelax
* Mucostop
* My 301
* Myocaine
* Myorelax
* Myoscaine
* Neurotone
* Oresol
* Oreson
* 1,2-Propanediol, 3-(2-methoxyphenoxy)-
* Propanosedyl
* Reduton
* Relaxyl-G
* Reorganin
* Resil
* Respenyl
* Respil
* Resyl
* Ritussin
* Robitussin
* Sirotol
* SL-90
* Tenntuss
* Trecid
* Tulyn
* XL-90
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1510 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year:
1,413,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 191,147,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,210,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Kidney, Ureter, Bladder - hematuria
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 85,323,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,429,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,398,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 495 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,398,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 15,1355,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,429,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,429,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
54,688,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2553 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATHPAB Applied Therapeutics. (Seccombe House Unlimited, Toronto, Canada)
V.2(9)-12, 1960-70. Volume(issue)/page/year: 9,55,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80423
No. of Facilities: 4214 (estimated)
No. of Industries: 5
No. of Occupations: 24
No. of Employees: 21971 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80423
No. of Facilities: 512 (estimated)
No. of Industries: 5
No. of Occupations: 13
No. of Employees: 25427 (estimated)
No. of Female Employees: 21545 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***