*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TZ0818000
CHEMICAL NAME           : 1,2-Propanediol, 3-(2-nitroimidazol-1-yl)-
CAS REGISTRY NUMBER     : 13551-92-3
BEILSTEIN REFERENCE NO. : 0613156
REFERENCE               : 5-23-04-00476 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C6-H9-N3-O4
MOLECULAR WEIGHT        : 187.18
WISWESSER LINE NOTATION : T5N CNJ A1YQ1Q BNW
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Demethylmisonidazole
   * Desmethylmisonidazole
   * 1-(2-Nitro-1-imidazolyl)-3-hydroxy-2-propanol
   * 3-(2-Nitroimidazol-1-yl)-1,2-propanediol
   * 3-(2-Nitro-1H-imidazol-1-yl)-1,2-propanediol
   * NSC 261036
   * 1,2-Propanediol, 3-(2-nitro-1H-imidazol-1-yl)-,
   * Ro 5-9963
   * SR 1530
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5076 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121212
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2532 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - contraction (isolated tissue)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121212
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2730 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 91,186,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4371540
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121204
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9020 mg/kg/20D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121212
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3340 mg/kg/20D-I
TOXIC EFFECTS :
   Behavioral - ataxia
   Blood - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121204
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2250 mg/kg/20D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Behavioral - ataxia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-121204
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 20 umol/L/20H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,207,1979
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 mmol/L/3D (Continuous)
REFERENCE :
   45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of
   Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W.,
   ed., New York, Masson Pub. USA, Inc., 1980  Volume(issue)/page/year:
   -,146,1980
 
                            *** END OF RECORD ***